Reducing weight in obese patients when used short-term and combined with exercise, diet, and behavioral modification.

Phentermine is an appetite suppressant. It works by helping to release certain chemicals in the brain that control appetite.

Phentermine works by stimulating the hypothalamus gland and affecting certain neurotransmitters to decrease appetite. The hypothalamus is the region of the brain that controls the autonomic nervous system, regulating sleep cycles, body temperature, appetite, etc.

Phentermine, like many other prescription drugs, works with neurotransmitters in the brain. It is a centrally-acting stimulant and is a constitutional isomer of methamphetamine. It stimulates neuron bundles to release a particular group of neurotransmitters known as catecholamines; these include dopamine, epinephrine (also known as adrenalin), and norepinephrine (noradrenaline). The anorectic activity seen with these compounds would thus seem likely due to this effect on the central nervous system, which is consistent with current knowledge about central nervous system systems and feeding behavior. This is the same mechanism of action as other stimulant appetite suppressants such as diethylpropion, and phendimetrazine.

The neurotransmitters signal a fight-or-flight response in the body which, in turn, puts a halt to the hunger signal. As a result, it causes a loss in appetite because the brain does not receive the hunger message.

Use Phentermine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Phentermine about 30 minutes before a meal.
• Take your last dose of Phentermine at least 4 to 6 hours before bedtime.
• If you are taking Phentermine 1 time a day, take your dose in the morning.
• If you miss a dose of Phentermine , take it as soon as possible. If it is after 12 pm and you are taking Phentermine 1 time a day, or after 4 pm and you are taking it more than 1 time a day, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Clinical use: Generally, it is recommended by the Food and Drug Administration (FDA) that Phentermine should be used short-term (usually interpreted as up to 12 weeks), while following nonpharmacological approaches to weight loss such as healthy dieting and exercise. However, recommendations limiting its use for short-term treatment may be controversial.

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